Differential cross sections of deep inelastic scattering of charged leptons from hadrons are investigated by using the gauge/string duality. We consider vector mesons derived from different holographic dual models obtaining a general expression. We focus on the strongly coupled regime of dual gauge theories for different values of the Bjorken parameter. We find new predictions which are particularly interesting for differential scattering cross sections of polarized leptons scattered off polarized vector mesons. We also carry out a detailed comparison of the moments of the structure functions with lattice QCD results.